临床内科杂志 ›› 2019, Vol. 36 ›› Issue (12): 819-822.doi: 10.3969/j.issn.1001-9057.2019.12.009

• 论 著 • 上一篇    下一篇

住院2型糖尿病患者甲状腺激素与慢性肾脏病检出率的关系

  

  • 出版日期:2019-12-15 发布日期:2019-12-30
  • 基金资助:
    安徽省蚌埠市科技局项目(20170320)

Relationship between the thyroid hormone and the detection rate of chronic kidney disease in hospitalized patients with type 2 diabetes mellitus

  • Online:2019-12-15 Published:2019-12-30

摘要: 目的 探讨住院2型糖尿病(T2DM)患者甲状腺激素与慢性肾脏病(CKD)检出率的关系。方法 纳入于我科住院的T2DM患者1118例,根据是否合并CKD将其分为CKD组205例和非CKD(NCKD)组913例,收集两组患者的临床资料并进行比较。采用多因素logistic回归分析评估与CKD相关的危险因素。结果 T2DM合并高血压患者中CKD检出率高于单纯T2DM患者(P<0.001)。CKD组患者年龄、高血压病程、T2DM病程、收缩压、舒张压、促甲状腺激素(TSH)水平均高于NCKD组,空腹血糖(FPG)、糖化血红蛋白(HbA1c)、总三碘甲腺原氨酸(TT3)、总甲状腺素(TT4)、游离三碘甲腺原氨酸(FT3)及游离甲状腺素(FT4)水平均低于NCKD组(P<0.05)。多因素logistic回归分析结果显示,FT3、T2DM病程、FPG、低密度脂蛋白胆固醇(LDL-C)、收缩压与蛋白尿伴估算的肾小球滤过率(eGFR)下降独立相关;FT3、性别及收缩压与蛋白尿独立相关;TT4、FT3、T2DM病程、年龄、LDL-C、舒张压与eGFR下降独立相关;FT3为蛋白尿、eGFR下降及蛋白尿伴eGFR下降的独立危险因素(P均<0.05)。结论 伴CKD的T2DM患者甲状腺激素水平与单纯T2DM患者不同,其中FT3是蛋白尿、eGFR下降及蛋白尿伴eGFR下降的独立危险因素,可能影响CKD的检出率。

关键词: 糖尿病; 慢性肾脏病; 检出率; 甲状腺激素

Abstract: Objective〓〖WT5”BZ〗To investigate the relationship between thyroid hormones and the detection〖JP〗 rate of chronic kidney disease(CKD) in hospitalized patients with type 2 diabetes mellitus(T2DM).〖WT5”HZ〗Methods〓〖WT5”BZ〗A total of 1118 T2DM patients were included in our department.All  patients were divided into CKD group and nonchronic kidney disease(NCKD) group according to whether accompanied with CKD.General and clinical data of the two groups were collected and compared.Multivariate logistic regression analysis was used to study the risk factors related to CKD.〖WT5”HZ〗Results〓〖WT5”BZ〗The detection rate of CKD in T2DM+hypertension(HP) patients was higher than that in T2DM patients(P<0.001).The age,course of HP,course of T2DM,systolic blood pressure,diastolic blood pressure and the level of thyrotrophin(TSH) in CKD group were higher than those in NCKD group,the level of fasting glucose(FPG),glycosylated hemoglobin(HbA1c),triiodinated thyroxine (TT3),free thyroxine(TT4),free triiodinated thyroxine (FT3) and free thyroxine (FT4) were lower than those in NCKD group(P<0.05).Multivariate logistic regression analysis showed that the level of FT3,course of T2DM,FPG,lowdensity lipoprotein(LDLC),systolic blood pressure were independently related to proteinuria accompanied estimated glomerular rate(eGFR) decrease,the level of FT3,gender and systolic blood pressure were independently related to proteinuria,the level of TT4,FT3,the course of T2DM,age,LDLC and diastolic blood pressure were independently related to eGFR decrease,FT3 was an independent risk factor for proteinuria,eGFR decrease and proteinuria with eGFR decrease.〖WT5”HZ〗Conclusion〓〖WT5”BZ〗The levels of thyroid hormone in T2DM patients with CKD are different from those in T2DM patients.FT3 is an independent risk factor for proteinuria,eGFR decrease,and proteinuria with eGFR decrease,it may affect the detection rate of CKD.

Key words: Diabetes mellitus; Chronic kidney disease; Detection rate; Thyroid hormone