Objective To explore the effects of hemodialysis and peritoneal dialysis on microinflammation of chronic renal failure（CRF）uremic patients and its relationship with cardiovascular disease.Methods A total of 120 CRF uremic patients treated in our hospital were divided into hemodialysis group(60 cases) and peritonealdialysis group(60 cases) according to the type of dialysis.After 6 months of treatment,the levels of C reactive protein(CRP)，tumor necrosis factor(TNF)-α，interleukin(IL)-1β，IL-6 btween the two groups were compared.Patients in the two groups were divided into the group with and without chronic heart failure(CHF) according to the presence or absence of combined with CHF,the levels of TNF-α、IL-1β，IL-6 in each group were compared.Results There were no significant differences in the levels of CRP,TNF-α,IL-1β，IL-6 between the two groups before treatment(P>0.05).After treatment,the levels of TNF-α,IL-1β，IL-6 in both groups were significantly reduced than the same group before treatment(P<0.05),the levels of TNF-α,IL-1β，IL-6 in the peritoneal dialysis group were lower than those in the hemodialysis group(P<0.05).In patients with CHF,the levels of TNF-α,IL-1β，IL-6 in patients of the group with heart failure were significantly higher than those in the same group of the group without heart failure(P<0.05).Conclusion Both hemodialysis and peritoneal dialysis can reduce the level of TNF-α,IL-1β，IL-6 in CRF uremic patients,and peritoneal dialysis is better.Microinflammation is correlated with cardiovascular disease.

Objective To explore the efficacy and safety of radiofrequency catheter ablation for ventricular arrhythmias originated from the right ventricular outflow tract(RVOT-VAs)and its influencing factors.Methods According to the success of a single operation or not,256 patients with RVOT-VAs undergoing radiofrequency catheter ablation were divided into successful single operation group(196 cases)and unsuccessful single operation group(60 cases),then general data and operational data of them were compared.Binary logistic regression analysis was performed to evaluate factors that affect the efficacy and safety of operation.Results In 256 patients,immediate success rate,single operation success rate and recurrence rate were 88.3%,76.6% and 13.2% respectively.Proportion of patients combined with hypertension and organic heart disease,QRS waves with various forms,surgical complications and pericardial tamponade in successful single operation group were lower than those in unsuccessful single operation group（P<0.05）.Results of binary logistic regression analysis showed that combining organic heart disease,lack of experience for operators and target site of catheter ablation locating in free wall were independent risk factors for failure of single operation（P<0.05）.Persistent ventricular tachycardial and target site of catheter ablation locating in free wall were independent risk factors for immediate failure of the first operation（P<0.05）.Combining organic heart disease,lack of experience for operators,target site of catheter ablation locating in free wall and QRS waves with various forms were independent risk factors for recurrence after the first operation（P<0.05）.Advanced age and lack of experience for operators were independent risk factors for complications during the first operation（P<0.05）.Conclusion There is high success rate and safety of radiofrequency catheter ablation treating RVOT-VAs.Combining organic heart disease,target site of catheter ablation locating in free wall and the operator’s experience are important factors which affect the efficacy and safety.

Objective To explore the changes of thyroid stimulating hormone(TSH) and thyroid hormone(TH) levels in type 2 diabetic patients with different body mass index(BMI) and waist circumference(WC) and the influence of obesity on TSH and TH.Methods A total of 275 hospitalized patients with type 2 diabetes were collected.They were divided into the normal group(18.5kg/m²≤BMI<24kg/m²，88 cases),overweight group(24kg/m²≤BMI<28kg/m²，90 cases) and obesity group(BMI≥28kg/m²，97cases) according to BMI.The blood lipid levels and thyroid function among these three groups were compared.Then,them were divided into M1 group（male WC<85cm）,M2 group（male WC≥85cm）,F1 group（female WC<80cm）,F2 group(female WC≥80cm) according to gender and WC.Make a comparison among the above indexes among these groups.Spearman correlation analysis was used to analyze correlation and multiple linear stepwise regression was used for influence factor analysis.Results Compared with the normal group,TSH levels in the overweight group and obesity group were significantly increased(P<0.05).TSH level in F2 group was obviously higher than those in F1 group and M2 group,and free thyroxine（FT₄） level was lower than that in M2 group(P<0.05).The results of correlation analysis showed that BMI of type 2 diabetic patients was positively correlated with TSH(r=0.25,P<0.05),TC was negatively related with FT₃(r=-0.39,P<0.05),and BMI and WC were negatively related with FT₄(r=-0.31,r=-0.29,P<0.05).The results of multiple linear stepwise regression showed that BMI was an independent correlative factor for TSH,and WC was an independent correlative factor for FT4(P<0.05).Conclusion The TSH level of obese patients with type 2 diabetes is increased,and FT4 is decreased，which are more obvious in female patients with abdominal obesity than those in males.

Objective To investigate the situation of vitamin D level in Chaoyang district of Beijing in recent two years,and explore the influencing factors of vitamin D deficiency and the correlation with blood lipid.Methods A cross sectional study was conducted to include 3905 subjects who underwent physical examination at Beijing first integrated traditional Chinese and western medicine hospital.Venous blood was taken to test 25-hydroxy-vitamin D[25(OH)D] and blood biochemical indexes.Multiple linear regression analysis was used to evaluate the correlation between 25(OH)D and blood lipid.Results The average serum 25(OH)D level of all subjects was(16.22±6.95) ng/ml,deficiency serious was found in 636 cases (16.29 %),deficiency was found in 2372 cases(60.74%),insufficiency was found in 713 cases(18.26%),plenty was found in 184 cases(4.71%).Subjects with different 25(OH)D levels had statistically significant differences in gender,age,weight,BMI,waist circumference,waist to hip ratio,systolic blood pressure,diastolic blood pressure,fasting plasma glucose(FPG),uric acid(UA),creatinine(Cr),total cholesterol(TC),triglyceride(TG),high-density lipoprotein cholesterol(HDL-C) and low-density lipoprotein cholesterol(LDL-C)(P<0.05).There were statistically significant differences in 25(OH)D levels among subjects of different gender(P=0.010),different BMI and gender(P=0.030) and physical examination in different season(P<0.001).Age distribution of subjects with different 25(OH)D levels was statistically significant(P＜0.001).The results of multiple linear regression analysis showed that 25(OH)D level was negatively correlated with TC(r=-0.35,P=0.016),TG(r=-0.28,P=0.046),LDL-C(r=-0.33,P=0.022),waist circumference(r=-0.30,P=0.035),waist to hip ratio(r=-0.30,P=0.032),and positively correlated with HDL-C(r=0.27,P=0.049).Conclusion Vitamin D deficiency in Chaoyang district of Beijing is common and should be paid attention.Vitamin D deficiency is associated with age,gender,seasonal variation，waist circumference,waist to hip ratio,BMI and blood lipid.

Objective To investigate the characteristics of major adverse cardiovascular events(MACE) and the risk of all-cause mortality in patients with diabetes mellitus and sepsis within 30 days of hospitalization.Methods A total of 720 patients with sepsis were enrolled.According to whether or not with diabetes mellitus,the patients were divided into diabetic group（n=252） and non-diabetic group（n=468）.The occurrence of MACE and all-cause mortality as well as the characteristics of MACE occurred on the 1st to 15th day(D₁₅) and the 16th to 30th day(D₃₀) were compared between the two groups.Results The incidence of MACE in the diabetic group was 36.5%,which was higher than that in non-diabetic group(22.2%，P<0.05),but there was no statistical difference in the incidence of acute cerebrovascular accidents between the two groups（P＞0.05）.The incidence of all-cause death in patients with diabetes was 25.0%,which was higher than that in non-diabetic group（15.6%，P<0.05).The incidences of ACS,acute heart failure,severe arrhythmia and cardiogenic death in D₁₅ of the two groups were respectively higher than those of D₃₀ in the same groups(P<0.05),but there was no statistical difference in the incidence of acute cerebrovascular accidents between D₁₅ and D₃₀ in both two groups（P＞0.05）.Multivariate logistic regression analysis showed that diabetes was an independent predictor of MACE(P<0.05).Conclusion In patients with diabetes mellitus and sepsis,the incidence of MACE and all-cause death during the 30day hospital stay increases significantly.Effective control of blood glucose may reduce MACE and all-cause mortality in sepsis patients with diabetes mellitus.