关键词: Graves病；血清磷代谢; 甲状腺激素

Abstract: Objective〓〖WT5”BZ〗To explore the correlation between serum phosphorus and thyroid function in Graves’disease patients.〖WT5”HZ〗Methods〓〖WT5”BZ〗A total of 348 newonset or recurrent Graves’ disease patients without medication were enrolled in our study,and their clinical data including electrolyte,liver and kidney function,thyroid function,thyrotropin receptor antibody（TRAb） and iodine uptake rate were collected.According to the normal high cutoff value for serum phosphorus（1.45mmol/L）,the patients were divided into hyperphosphatemic group and normophosphatemic group.Nonparametric test was used to analyze the different parameters between the two groups,and logistic regression analysis was used to analyze the related factors that might affect serum phosphorus level.〖WT5”HZ〗Results〓〖WT5”BZ〗The incidence of hyperphosphatemia was 41.38%（144/348）.Patients in hyperphosphatemic group showed that age and BMI were lower than those in normophosphatemic group(P<0.05),while triiodothyronine（T3），free triiodothyronine（FT3）TRAb,3h radioactive iodine uptake（3h RAIU）,24h radioactive iodine uptake（24h RAIU） and calcium(Ca) were higher than those in normophosphatemic group(P<0.05).BMI（r=-0.158）,T3（r=-0.146）,FT3(r=0.188),3h RAIU(r=0.159) and 24h RAIU(r=0.186) are correlated with serum phosphorus〖JP3〗(P<0.05).Logistic regression analysis indicated that age（OR=0.982,95%CI 0.966～0.998,P=0.032）,〖JP〗gender（OR=0.555,95%CI 0.346～0.891,P=0.015) and FT3（OR=0.555,95%CI 0.346～0.891,P=0.015) were the relative factors for hyperphosphatemia..〖WT5”HZ〗Conclusion〓〖WT5”BZ〗There is abnormal phosphorus metabolism in Graves’disease patients.Patients of younger age,female and elevated FT3 are more likely to suffer hyperphosphatemia.

Key words: Graves’disease; Phosphorus metabolism; Thyroid hormone