临床内科杂志 ›› 2019, Vol. 36 ›› Issue (9): 605-607.doi: 10.3969/j.issn.10019057.2019.09.009

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血清维生素水平与肺腺癌转移的相关性

  

  • 出版日期:2019-09-15 发布日期:2019-09-30

Correlation between serum level of vitamins and metastasis of lung adenocarcinoma

  • Online:2019-09-15 Published:2019-09-30

摘要: 目的 探讨血清9种维生素水平与肺腺癌转移的相关性。方法 回顾性分析2016年1月~2018年8月于我院就诊的201例肺腺癌患者的临床资料。依据肿瘤有无转移将其分为转移组132例和非转移组69例;依据肿瘤转移器官和转移灶数量将转移组132例患者分为寡转移组73例和多发转移组59例。检测各组患者外周血9种维生素水平并进行比较分析。结果 非转移组和转移组患者年龄及性别、吸烟史、家族史、规律锻炼、每日日照时间、水果摄入、饮食均衡情况构成比比较,差异均无统计学意义(P>0.05)。非转移组和转移组患者血清维生素水平主要以缺乏为主,且血清维生素缺乏主要表现为维生素A、维生素B2、维生素C及维生素D缺乏;血清维生素过量相对少见。非转移组和转移组患者血清维生素A、维生素B1、维生素B2、维生素B6、维生素B9、维生素B12、维生素C、维生素D、维生素E水平比较,差异均无统计学意义(P>0.05)。多发转移组患者血清维生素D水平低于寡转移组(P<0.05),而多发转移组和寡转移组患者血清维生素A、维生素B1、维生素B2、维生素B6、维生素B9、维生素B12、维生素C、维生素E水平比较,差异均无统计学意义(P>0.05)。结论 维生素D可能在肺腺癌转移中起一定抑制作用。

关键词: 肺腺癌; 血清维生素水平; 转移特征; 寡转移

Abstract: Objective To explore the correlation between level of nine vitamins and metastasis of lung adenocarcinoma.Methods Clinical data of 201 patients with lung adenocarcinoma in our hospital from January 2016 to August 2018 were analyzed retrospectively.They were divided into metastasis group(132 cases) and non-metastasis group(69 cases) according to tumor metastasis or not.The 132 patients in metastasis group were divided into oligo-metastasis group(73 cases) and multiple-metastatic group(59 cases) according to number of tumor metastatic organs and metastatic lesions.Levels of serum nine vitamins were measured and compared between each group.Results There were no significant differences of age and composition ratio of sex,smoking history,family history,regular exercise,daily sunshine time,fruit intake and diet balance between non-metastasis group and metastasis group(P>0.05).Levels of serum vitamins in patients of non-metastasis group and metastasis group were mainly deficient,such as vitamin A,vitamin B2,vitamin C and vitamin D deficiency.Overdose of serum vitamins were relatively rare.There were no significant differences of levels of serum vitamin A,B1,B2,B6,B9,B12,C,D and E between non-metastasis group and metastasis group(P>0.05).Level of serum vitamin D in multiple metastasis group was lower than that in oligo-metastasis group(P<0.05).While there were no significant differences of levels of serum vitamin A,B1,B2,B6,B9,B12,C and E between multiple-metastasis group and oligo-metastasis group(P>0.05).Conclusion Vitamin D may play a role in inhibition of metastasis of lung adenocarcinoma.   

Key words: Lung adenocarcinoma; Vitamin; Metastasis