Journal of clinical internal medicine ›› 2019, Vol. 36 ›› Issue (10): 685-688.doi: 10.3969/j.issn.1001-9057.2019.10.012
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Abstract: Objective〓〖WT5”BZ〗To explore the correlation between serum phosphorus and thyroid function in Graves’disease patients.〖WT5”HZ〗Methods〓〖WT5”BZ〗A total of 348 newonset or recurrent Graves’ disease patients without medication were enrolled in our study,and their clinical data including electrolyte,liver and kidney function,thyroid function,thyrotropin receptor antibody(TRAb) and iodine uptake rate were collected.According to the normal high cutoff value for serum phosphorus(1.45mmol/L),the patients were divided into hyperphosphatemic group and normophosphatemic group.Nonparametric test was used to analyze the different parameters between the two groups,and logistic regression analysis was used to analyze the related factors that might affect serum phosphorus level.〖WT5”HZ〗Results〓〖WT5”BZ〗The incidence of hyperphosphatemia was 41.38%(144/348).Patients in hyperphosphatemic group showed that age and BMI were lower than those in normophosphatemic group(P<0.05),while triiodothyronine(T3),free triiodothyronine(FT3)TRAb,3h radioactive iodine uptake(3h RAIU),24h radioactive iodine uptake(24h RAIU) and calcium(Ca) were higher than those in normophosphatemic group(P<0.05).BMI(r=-0.158),T3(r=-0.146),FT3(r=0.188),3h RAIU(r=0.159) and 24h RAIU(r=0.186) are correlated with serum phosphorus〖JP3〗(P<0.05).Logistic regression analysis indicated that age(OR=0.982,95%CI 0.966~0.998,P=0.032),〖JP〗gender(OR=0.555,95%CI 0.346~0.891,P=0.015) and FT3(OR=0.555,95%CI 0.346~0.891,P=0.015) were the relative factors for hyperphosphatemia..〖WT5”HZ〗Conclusion〓〖WT5”BZ〗There is abnormal phosphorus metabolism in Graves’disease patients.Patients of younger age,female and elevated FT3 are more likely to suffer hyperphosphatemia.
Key words: Graves’disease, Phosphorus metabolism, Thyroid hormone
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http://www.lcnkzz.com/EN/Y2019/V36/I10/685
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