Abstract:

Objective  To evaluate the relationship between thyroid stimulating hormone(TSH) level and insulin resistance(IR) in obese non-diabetic patients.Methods  Obese non-diabetic patients who were treated in the clinic of endocrinology department in people’s hospital of Fufeng county from August 2016 to May 2018 were selected as subjects.The clinical data,laboratory results and thyroid morphological and functional evaluation results were collected.The relationship of TSH level and insulin resistance index(HOMA-IR) were computed using multivariate linear regression analysis.Results  TSH level was positively correlated with HOMA-IR(r=0.24,P=0.028),serum insulin(r=0.23,P=0.037)and triglyceride(r=0.30,P=0.006)in the overall cohort,while negatively correlated with serum high density lipoprotein cholesterol(r=-0.25,P=0.002).HOMA-IR was positively correlated with triglyceride(r=0.25,P=0.026),ALT(r=0.37,P=0.001)and amplification of glutamyl transpeptidase(r=0.32,P=0.003).The results of multivariate linear regression analysis showed that TSH(β=0.620,95%CI 0.482-0.758,P=0.015)and BMI(β=0.147,95%CI 0.111-0.184,P=0.034)were significantly correlated with HOMA-IR.Conclusion  TSH is associated with insulin resistance in obese non-diabetic patients,suggesting that the screening of thyroid function is important for obese non-diabetic patients.

Key words: Obesity, Non-diabetes, Insulin resistance, Thyroid hormones, Thyroid function