Abstract: Objective To explore the correlation between level of nine vitamins and metastasis of lung adenocarcinoma.Methods Clinical data of 201 patients with lung adenocarcinoma in our hospital from January 2016 to August 2018 were analyzed retrospectively.They were divided into metastasis group(132 cases) and non-metastasis group(69 cases) according to tumor metastasis or not.The 132 patients in metastasis group were divided into oligo-metastasis group(73 cases) and multiple-metastatic group(59 cases) according to number of tumor metastatic organs and metastatic lesions.Levels of serum nine vitamins were measured and compared between each group.Results There were no significant differences of age and composition ratio of sex,smoking history,family history,regular exercise,daily sunshine time,fruit intake and diet balance between non-metastasis group and metastasis group(P>0.05).Levels of serum vitamins in patients of non-metastasis group and metastasis group were mainly deficient,such as vitamin A,vitamin B₂,vitamin C and vitamin D deficiency.Overdose of serum vitamins were relatively rare.There were no significant differences of levels of serum vitamin A,B₁,B₂,B₆,B₉,B₁₂,C,D and E between non-metastasis group and metastasis group(P>0.05).Level of serum vitamin D in multiple metastasis group was lower than that in oligo-metastasis group(P＜0.05).While there were no significant differences of levels of serum vitamin A,B₁,B₂,B₆,B₉,B₁₂,C and E between multiple-metastasis group and oligo-metastasis group(P>0.05).Conclusion Vitamin D may play a role in inhibition of metastasis of lung adenocarcinoma.   

Key words: Lung adenocarcinoma, Vitamin, Metastasis