Abstract: Objective To explore the short-term variation and related factors of serum calcium and phosphorus after parathyroidectomy(PTX) in patients with secondary hyperparathyroidism (SHPT).Methods A total of 18 patients treated with PTX for intractable SHPT in our hospital were analyzed retrospectively.Baseline data and serum intact parathyroid hormone(iPTH),serum alkaline phosphatase(ALP),serum calcium and phosphorus of all patients on the first，the third and the seventh day after PTX were collected and compared.The calcium requirements in a week after PTX were collected.Pearson and Spearman correlation analysis were used to analyze the correlation among preoperative serum iPTH,serum calcium,serum phosphorus,serum ALP and calcium requirements in a week after the operation.Results Serum iPTH and phosphorus of all patients on the first，the third and the seventh day after PTX were significantly decreased than those before PTX(P＜0.05).Serum ALP on the first day after PTX was significantly decreased than that before PTX(P＜0.05).Serum calcium on the seventh day after PTX was significantly decreased than that before PTX(P＜0.05).Serum iPTH level before PTX was positively correlated with serum ALP level before PTX(r=0.773,P＜0.001).Calcium requirements in a week after PTX were positively correlated with serum iPTH level(r=0.855,P＜0.001) and ALP level(r=0.925,P＜0.001)before PTX.Conclusion PTX is a safe and effective treatment for intractable SHPT，which can quickly correct the metabolic disorder of serum calcium and phosphorus in short time.

Key words: Parathyroidectomy, Secondary hyperparathyroidism