Abstract: Objective To explore the predictive value of QT interval after correction（QTc） prolongation in electrocardiogram for delayed neuropsychiatric sequelae(DNS) in patients with carbon monoxide(CO) poisoning.Methods Clinical data of 223 patients with CO poisoning were retrospectively analyzed,the patients were divided into DNS group(31 cases) and non-DNS group(202 cases).Univariate and multivariate logistics regression analysis were used to determine independent risk factors for DNS occurrence,the predictive value of QTc detecting time for DNS was evaluated by ROC curve.Results DNS occurred in 31 cases(13.3%) of the 233 patients with CO poisoning.Univariate logistic regression analysis showed that the Glasgow coma score(GCS)<9 points,transient loss of consciousness,CO exposure to prolonged hospital admission and QTc prolongation were associated with DNS(P<0.05).Multivariate logistic regression analysis showed that the GCS score<9 points,CO exposure to admission time>6h and QTc prolongation were independent risk factors for DNS deveplement(P<0.05).ROC curve analysis showed that QTc detection within CO exposure<2h,2~4h,4~6h had high predictive value for DNS development,and with the best predicted value of within 6 hours of CO exposure.Conclusion QTc prolongation within 6h of CO exposure is a new index for predicting DNS occurrence in patients with CO poisoning.

Key words: Carbon monoxide poisoning, Delayed neuropsychiatric sequelae, QT interval after correction prolongation