Abstract: Objective To explore the clinical characteristics of patients with pre-hypertension accompanied by increased hemoglobin(Hb) level and effect of high-salt diet on their long-term prognosis.Methods A total of 421 patients with pre-hypertension were divided into group A(Hb≤138g/L,217 cases) and group B(Hb>138g/L,204 cases) according to baseline median Hb level dichotomies.Clinical data and prognosis of the two groups were compared.At the same time,patients in group B were divided into high salt group(117 cases) and normal salt group(87 cases) according to the salt intake.Clinical data and prognosis of the two groups were compared.Cox regression analysis was used to assess risk factors for developing hypertension and MACCE during follow-up in group B patients.Results Proportions of patients with single coronary artery lesion,Gensini score and number of diseased coronary arterys in group A were lower than those in group B,while proportion of patients with no coronary artery lesion was higher than those in group B(P＜0.05).During follow-up,proportions of patients with hypertension and MACCE in group B were higher than those in group A(P＜0.05).Kaplan-Meier curve analysis showed that incidences of hypertension and MACCE in patients of goup B were higher than those of group A(P＜0.05).Cox regression analysis showed that both high salt diet and diabetes history were independent risk factors for hypertension and MACCE during follow-up in group B(P＜0.05).Proportions of patients with MACCE in high salt group was higher than those in normal salt group(P＜0.05).Kaplan-Meier curve analysis showed that incidence of hypertension and MACCE in high salt group were higher than those in normal salt group(P＜0.05).Conclusion Coronary lesions in patients with pre-hypertension accompanied by increased Hb level is serious Incidence rates of hypertension and MACCE during follow-up are high,and high salt diet can furtherly lead to the occurrence of hypertension and MACCE.

Key words: Prehypertension, Hemoglobin, Highsalt diet, Hypertension